Technology Partnership of Nagoya University, Inc.

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Available Technologies

BIOTECH & AGRICULTURAL TECHNOLOGIES

 

(for more information, click title to open PDF file)

A-62     Genome-based Chemically Synthesized Cyclic Peptide Library for Phenotypic screening

The researchers have developed cyclic peptide library that is applicable to phenotypic screening. The structure of each cyclic peptides is designed from genome information.

B-22     Novel Method for Inter-Family Grafts

Grafting has been used historically to enhance yields or to increase tolerance against environmental stress and plant diseases.

 

B-23     Parasitic Striga Germination Inducer

The parasitic plant Striga Hermonthica causes damage to crops like corn, rice, and peas/beans in Africa, Asia, the USA and Africa.

 

B-26     Clearsee: A Rapid Optical Clearing Reagent for Whole-Plant Fluorescent Imaging

Nagoya University researchers have invented an aqueous chemical reagent, termed ClearSee, that renders fixed plant tissues transparent to allow deep imaging by chemical screening. ClearSee rapidly diminishes chlorophyll autofluorescence while preserving the fluorescence of fluorescence proteins.

 

B-27     High Concentrated Sucrose from Rice

Nagoya University researchers have revealed that POEM (pollen tube-dependent ovule enlargement morphology) by mutation of gcs1 gene in Oryza sativa (rice) can allow the storage of a highly concentrated sucrose (98%) as a liquid.

 

B-28     Novel Fluorescent Compounds that Distinguish DNA and RNA

Nagoya University researchers have succeeded in developing novel fluorescent compounds that allow users to overcome all current fluorescent dye problems. These novel compounds can be used to stain living cells well (< 500 MW) without any damage using low energy wavelength excitation (561 nm) and they are applicable to the two-photon excitation microscopy assay.

B-30     Photoresistant Fluorescent Dyes for Bioimaging

Researchers at Nagoya University have developed novel fluorescent dyes, based on a benzophosphole scaffold.

B-31     Novel synthetic auxin and its receptor that control gene expressions at specific part of the plant

Nagoya University researchers have succeeded in developing the auxin receptor (TIR1F79G) *by mutating an amino acid residue, and the novel synthetic auxin (27B) that specifically binds to TIR1F79G.

B-32     A Vector for Highly Efficient CRISPR/Cas9-Mediated Genome Engineering in Arabidopsis

Researchers at Nagoya University prepared three patterns of promoters to express Cas9.

B-33     Water Film Device for Continuous Particulate Matter Collection

Nagoya University researchers have developed a continuous PM2.5 collection system from aerosol using a water film within the device. The water film is formed by a superhydrophilic surface and enables the collection of PM2.5 from gas phase.

A-61     Antibody that Inhibits Wnt Signal Activation Pathway

Although it is known that ADAM family proteases cause the severe bleeding from haemorrhagic snake venom, the detailed mechanism of the haemorrhage is unclear. Researchers at Nagoya University have found that the target of ADAM proteases is a Wnt/β-catenin signal receptor, LRP5/6 which controls cell differentiation and proliferation.

B-34     Novel compounds that keep plant fresh: Controlling stomatal aperture

Through random screening of a chemical library of over 20,000 compounds, Nagoya University researchers have succeeded in finding new compounds that can control stomatal opening in plants.

B-40     ROR1: Novel Therapeutic Target for Lung Adenocarcinoma

Nagoya University researchers have successfully elucidated functional molecular mechanism of the receptor tyrosine kinase-like orphan receptor 1 (ROR1) to develop molecular targeted drugs of lung adenocarcinoma. 

 
B-41     Mesial Temporal Lobe Epilepsy Mouse Model ( pi/ pi mice)

The adult  pi/ pi mouse is a mutant mouse that constantly exhibit generalized tonic- clonic seizures (GTCSs; alternatively, grand-mal seizures) for life (up to two years) without any epileptogenic induction.

 
B-42     Novel Green Method to Convert Benzene to Phenol

Nagoya University researchers have succeeded in developing an Escherichia coli whole-cell biocatalyst for the direct hydroxylation of  benzene into phenol. This in vivo method enables wild-type cytochrome P450BM3 (P450BM3) expressed in E.coli to activate and hydroxylate its non-native substrates, such as benzene.